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From Sourcing Signals to Pipeline Advantage: External R&D Best Practice Playbook

This playbook is intended to serve as a blueprint for building External R&D functions that can source the right science early, evaluate it efficiently, and translate external intelligence into lasting pipeline advantage.

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From Sourcing Signals to Pipeline Advantage: External R&D Best Practice Playbook

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Contributors

The insights contained within this resource were given by the following industry leaders...

Uli Stilz
Uli Stilz
Senior Partner, Pioneering Medicines Partnerships at Flagship Pioneering

Over more than three decades in the pharmaceutical and biotechnology industry, Uli has contributed to the discovery and development of numerous therapeutic candidates while leading external innovation, strategic partnerships, and portfolio-building efforts across Europe and the United States.

David Lough
David Lough
Director, Academic Partnerships, Open Innovation at Chiesi
Jean Baptiste de Peretti
Jean Baptiste de Peretti
Director, Global Partnering at Ipsen
Nick Spirit
Nick Spirit
Senior Director, External Innovation Solutions at Inpart

What’s inside the playbook?

  • A five-pillar framework for building External R&D capability, from ecosystem positioning through to pipeline contribution
  • The External R&D workflow, showing how the pillars come together in practice
  • A self-assessment to benchmark your function against each pillar and identify where to focus

Who is the playbook for?

  • Heads of External R&D, Open Innovation, and Scientific Partnering building or maturing their sourcing capability
  • BD and BD&L leaders who want to strengthen how external science enters the pipeline
  • R&D leaders accountable for pipeline sustainability and the return on external innovation
  • Partnering and alliance teams working to connect early sourcing with long-term collaboration

How is AI changing External R&D for companies?

Every External R&D team faces the same structural problem: the inflow of science is uncontrolled, the budget is set elsewhere, and the team is a fixed size, so the only real lever is where the team puts its attention. This is where AI changes the economics by expanding how much a team can see, triage, and remember without growing headcount.

The playbook examines where AI genuinely changes External R&D, and where human judgment still decides.

What makes External R&D teams successful?

Successful External R&D teams do three things well: they source the right science early, evaluate it efficiently, and turn external intelligence into lasting pipeline advantage.

This playbook is a blueprint for building that capability, developed with experienced External R&D leaders in the industry and grounded in Inpart's work with partnering teams at the world's leading pharma companies.

The five pillars of external R&D excellence

I

Ecosystem Positioning

Over Asset Processing

II

Strategic Search Spaces

Over Opportunistic Sourcing

III

Institutional Memory

As Competitive Moat

IV

Empowered Scouts

Within Governed Boundaries

V

Pipeline Contribution

Over Deal Volume